High-Dose Ibuprofen in Cystic Fibrosis
نویسندگان
چکیده
منابع مشابه
High-Dose Ibuprofen in Cystic Fibrosis
Cystic Fibrosis (CF) is the most common lethal genetic disorder in North America and Europe. Most patients succumb to progressive lung disease characterized by an exaggerated neutrophilic inflammation. In animal models of chronic infection, high-dose ibuprofen was demonstrated to reduce inflammation without hindering bacterial clearance. This led to two clinical trials, which demonstrated a ben...
متن کاملPopulation pharmacokinetics of high dose ibuprofen in cystic fibrosis.
AIMS To evaluate ibuprofen population pharmacokinetics in a large series of data collected in children with cystic fibrosis (CF) treated with high doses of ibuprofen (59 patients; 2-18 years), and to identify the main causes responsible for the considerable interindividual variability in ibuprofen serum levels. METHODS Blood samples were collected during routine clinical care; serum ibuprofen...
متن کاملIbuprofen Inhibits Cystic Fibrosis Transmembrane Conductance
We evaluated the acute effects of ibuprofen and salicylic acid on cAMP-mediated Cl 2 secretion (I sc ) in both colonic and airway epithelia. In T84 cells, ibuprofen inhibited the forskolin-dependent I sc in a concentration-dependent manner, having an apparent K i of 142 m M. Salicylic acid inhibited I sc with an apparent K i of 646 m M. We determined whether ibuprofen would also inhibit the for...
متن کاملHigh-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis: a case report
BACKGROUND Lung disease in patients with cystic fibrosis is thought to develop as a result of airway inflammation, infection, and obstruction. Pulmonary therapies for cystic fibrosis that reduce airway inflammation include corticosteroids, rhDNase, antibiotics, and high-dose ibuprofen. Despite evidence that high-dose ibuprofen slows the progression of lung disease in patients with cystic fibros...
متن کاملIbuprofen regulation of microtubule dynamics in cystic fibrosis epithelial cells.
High-dose ibuprofen, an effective anti-inflammatory therapy for the treatment of cystic fibrosis (CF), has been shown to preserve lung function in a pediatric population. Despite its efficacy, few patients receive ibuprofen treatment due to potential renal and gastrointestinal toxicity. The mechanism of ibuprofen efficacy is also unclear. We have previously demonstrated that CF microtubules are...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmaceuticals
سال: 2010
ISSN: 1424-8247
DOI: 10.3390/ph3072213